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portada Neuroinflammatory Mechanisms in Alzheimer's Disease: Basic and Clinical Research
Type
Physical Book
Publisher
Author
Language
English
Pages
263
Format
Paperback
Dimensions
23.4 x 15.6 x 1.5 cm
Weight
0.40 kg.
ISBN13
9783034895293
Categories

Neuroinflammatory Mechanisms in Alzheimer's Disease: Basic and Clinical Research

Rogers, Joseph (Author) · Birkhauser · Paperback

Neuroinflammatory Mechanisms in Alzheimer's Disease: Basic and Clinical Research - Rogers, Joseph

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Synopsis "Neuroinflammatory Mechanisms in Alzheimer's Disease: Basic and Clinical Research"

Research into inflammatory mechanisms that may cause damage to the Alzheimer's disease (AD) brain has now been ongoing for nearly two decades. Some two dozen clinical studies have strongly suggested that conventional anti-inflammatory drugs may be useful to delay the onset or slow the progression of the disorder. Moreover, virtually all the major systems of the innate immune response appear to be present, and most are upregulated, in pathologically-vulnerable regions of the AD brain. These new findings are described in this volume - first in overview form, followed by chapters on topics of special interest. In many ways, to understand AD brain inflammation, one need only review a text on peripheral inflammation biology, leaving out the chapters on humoral medi- ators and substituting microglia for macrophages. In several other key respects, however, AD brain inflammation is unique, due primarily to idiosyncratic interac- tions of inflammatory mediators and mechanisms with classical AD pathology: amyloid peptide(A ) deposits and neurofibrillary tangles (NFTs). For this reason, some key concepts about the inflammation that occurs in AD may warrant discus- sion in preparation for the more detailed chapters that follow.

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