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portada Natural Killer Cells Phenotype and Hepatitis c Virus Infection
Type
Physical Book
Publisher
Author
Language
English
Pages
136
Format
Paperback
ISBN13
9783659788031

Natural Killer Cells Phenotype and Hepatitis c Virus Infection

Somaya El-Deeb; Hosni Salama; Asmaa Elsayed (Author) · Lap Lambert Academic Publishing · Paperback

Natural Killer Cells Phenotype and Hepatitis c Virus Infection - Somaya El-Deeb; Hosni Salama; Asmaa Elsayed

New Book Imported to Austria
Delivery: 11 Sep - 15 Sep Shipping: 13 to 14 business days.
81,98 €
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81,98 €

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Synopsis "Natural Killer Cells Phenotype and Hepatitis c Virus Infection"

During the early phases of a hepatitis C virus (HCV) infection, natural killer (NK) cells activation appears to be critical in the innate immune responses that have the potential of clearing the infection. Impaired activity of NK cells has been proposed as a mechanism contributing to viral persistence and chronic infection in HCV infection. We aim to assess the impact of HCV infections on NK cells regarding frequency, and subset distribution. The correlation between the phenotype of NK subsets and the various stages was assayed. Number of total NK cells was significantly reduced and a striking shift in NK subsets, with a marked decrease in the CD56-dim cell fraction compared to CD56-bright cells was identified. The number of Nk cells bearing the inhibitory receptor CD158b(KIR) increased in HCV patients at advanced stages, whereas those bearing activating receptors CD314(NKG2D), CD161 were significantly reduced as compared to normal.

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