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portada G Protein Methods and Protocols: Role of G Proteins in Psychiatric and Neurological Disorders
Type
Physical Book
Publisher
Author
Language
English
Pages
433
Format
Paperback
Dimensions
22.9 x 15.2 x 2.3 cm
Weight
0.59 kg.
ISBN13
9781489942906
Categories

G Protein Methods and Protocols: Role of G Proteins in Psychiatric and Neurological Disorders

Mishra, Ram K. ; Baker, Glen B. ; Boulton, Alan A. (Author) · Humana · Paperback

G Protein Methods and Protocols: Role of G Proteins in Psychiatric and Neurological Disorders - Mishra, Ram K. ; Baker, Glen B. ; Boulton, Alan A.

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Synopsis "G Protein Methods and Protocols: Role of G Proteins in Psychiatric and Neurological Disorders"

The G proteins are a family of structurally homologous, plasma membrane-associated guanine-nucleotide-binding proteins. These proteins play an integral role in the tra- duction of extracellular signals through second messenger systems. As such, G proteins affect a wide variety of intra cellular biochemical reactions by regulating the concent- tion of second messengers in cells. G proteins are heterotrimeric, consisting of a, p, and y polypeptide chains, with G protein specificity largely det- mined by the a-subunit, Molecular cloning of G protein s- units has revealed 23 distinct a-subunits, encoded by 17 different genes. Based on functional measures, G proteins are generally classified into three major categories: the G, family, which is stimulatory for adenylyl cyclase; the G, f- ily, which is inhibitory for adenylyl cyclase; and the G, f- ily, which stimulates phospholipases (Birnbaumer and Birnbaumer, 1995). Alternatively, on the basis of sequence homology, G proteins can be subdivided into four cate- ries: G, G, G, and G12.

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