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portada Virus Variability, Epidemiology and Control: Virus Variability, Epidemiology and Control v. 2 (Applied Virology Research)
Type
Physical Book
Publisher
Author
Year
1990
Language
English
Pages
368
Format
Hardcover
ISBN
0306433591
ISBN13
9780306433597
Edition No.
1990
Categories

Virus Variability, Epidemiology and Control: Virus Variability, Epidemiology and Control v. 2 (Applied Virology Research)

Kurstak Edouard Ed (Author) · Springer · Hardcover

Virus Variability, Epidemiology and Control: Virus Variability, Epidemiology and Control v. 2 (Applied Virology Research) - Kurstak Edouard Ed

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Synopsis "Virus Variability, Epidemiology and Control: Virus Variability, Epidemiology and Control v. 2 (Applied Virology Research) "

Virus Variability and Impact on Epidemiology and Control of Diseases E. Kurstak and A. Hossain I. INTRODUCTION An important number of virus infections and their epidemic developments demonstrate that ineffec­ tiveness of prevention measures is often due to the mutation rate and variability of viruses (Kurstak et al., 1984, 1987). The new human immunodeficiency retroviruses and old influenza viruses are only one among several examples of virus variation that prevent, or make very difficult. the production of reliable vaccines. It could be stated that the most important factor limiting the effectiveness of vaccines against virus infections is apparently virus variation. Not much is, how­ ever, known about the factors influencing and responsible for the dramatically diverse patterns of virus variability. II. MUTATION RATE AND VARIABILITY OF HUMAN AND ANIMAL VIRUSES Mutation is undoubtedly the primary source of variation, and several reports in the literature suggest that extreme variability of some viruses may be a consequence of an unusually high mutation rate (Holland et al., 1982; Domingo et al., 1985; Smith and Inglis, 1987). The mutation rate of a virus is defined as the probability that during a single replication of the virus genome a particular nucleotide position is altered through substitution, deletion, insertion. or recombination. Different techniques have been utilized to measure virus mutation rates, and these have been noted in the extent of application to different viruses.

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