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portada The Biology and Pathology of Innate Immunity Mechanisms
Type
Physical Book
Publisher
Author
Language
English
Pages
330
Format
Paperback
Dimensions
23.4x15.6x1.8 cm
Weight
0.49 kg.
ISBN13
9781475786477
Categories

The Biology and Pathology of Innate Immunity Mechanisms

Keisari, Yona ; Ofek, Itzhak (Author) · Springer · Paperback

The Biology and Pathology of Innate Immunity Mechanisms - Keisari, Yona ; Ofek, Itzhak

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Synopsis "The Biology and Pathology of Innate Immunity Mechanisms"

In recent years increased scientific attention has been given to immediate defense mechanisms based on non-clonal recognition of microbial components. These mechanisms constitute the innate immunity arm of the body s defense. Identification of pathogens by these mechanisms involves primarily receptors recognizing sugar moieties of various microorganisms. Innate immunity based mechanisms are essential for the existence of multicellular organisms. They are evolutionarily conserved and designed to provide immediate protection against microbial pathogens to eradicate infection. Activation of innate immunity is crucial for transition to specific immunity and for its orientation, and to assist the specific immune response in the recognition of pathogens and their destruction. Innate immunity is regularly involved in the arrest of bacterial, mycotic, viral and parasitic infections, giving the specific immune response time to become effective. It becomes critically essential in immunocompromised patients who fail to mount specific immune responses due to congenital or acquired immunodeficiencies as a result of chemotherapy, dialysis, immunosuppressive drugs, or HIV infection. The Innate Immunity arsenal constitutes polymorphonuclear and mononuclear phagocytes, mast cells, the complement system, Natural Killer cells, antimicrobial peptides, and presumably a subset of T lymphocytes with TCRl receptors.

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