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portada Murine Interferon Regulatory Factor-2 (IRF-2) and Escherichia coli
Type
Physical Book
Author
Publisher
Language
English
Pages
116
Format
Paperback
Dimensions
22.9 x 15.2 x 0.7 cm
Weight
0.18 kg.
ISBN13
9786139861019
Categories

Murine Interferon Regulatory Factor-2 (IRF-2) and Escherichia coli

Ajeet Kumar (Author) · Krishna Prakash (Author) · LAP Lambert Academic Publishing · Paperback

Murine Interferon Regulatory Factor-2 (IRF-2) and Escherichia coli - Prakash, Krishna ; Kumar, Ajeet

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Synopsis "Murine Interferon Regulatory Factor-2 (IRF-2) and Escherichia coli"

Interferon Regulatory Factor-2 is a vertebrate transcription factor having oncogenic nature; it antagonises Interferon Regulatory Factor-1, a tumor suppressor gene, functions. Knockout mice for IRF-2 gene showed defect in B-cell lymphopoeisis, they died following LCMV (Lymphocytic Choriomeningitis Virus) infections. IRF-2 is functionally just opposite of IRF-1. Interestingly, one would have thought that as IRF-1-/- (knock-out) mice showed lack of CD8+T cells and low cytotoxicity of NK cells, the over production of IRF-2 in mice may restore it. But it does not happen so, the reason being unknown. However, IRF-2 binds at Interferon Stimulated Response Element sequence in viral infected cell. This book is about mouse IRF-2 gene cDNA cloning and expression of chimeric protein in E.coli. This study will serve as a platform for further functional analysis of chimeric IRF-2, which is potent oncogene in aberrant conditions.

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