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portada Dual Drug Action of Drug Delivery System
Type
Physical Book
Publisher
Author
Language
English
Pages
80
Format
Paperback
ISBN13
9783659787454

Dual Drug Action of Drug Delivery System

Pramod Kumar Biswal; Manoj Kumar Mishra; Anupam Singh Bhaodouriya (Author) · Lap Lambert Academic Publishing · Paperback

Dual Drug Action of Drug Delivery System - Pramod Kumar Biswal; Manoj Kumar Mishra; Anupam Singh Bhaodouriya

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Synopsis "Dual Drug Action of Drug Delivery System"

The purpose of the present research was to produce a quick/slow biphasic delivery system for Diclofenac Sodium. A dual component tablet made of a sustained release tableted core and an immediate release tableted coat was prepared by direct compression. Both the core and the coat contained a model drug (Diclofenac Sodium). The sustained release effect was achieved with a polymer (Microcrystalline cellulose) to modulate the release of the drug. The in vitro drug release profile from these tablets showed the desired biphasic release behavior: the Diclofenac Sodium contained in the fast releasing component was dissolved within 2 minutes, whereas the drug in the core tablet was released at different times (≈16 or 924 hours), depending on the composition of the matrix tablet. Based on the release kinetic parameters calculated, it can be concluded that the Micro Crystalline core was suitable for providing a constant and controlled release (zero order) for a long period of time.

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