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portada retrotransposition, diversity and the brain
Type
Physical Book
Illustrated by
Publisher
Author
Year
2010
Language
English
Pages
123
Format
Paperback
Dimensions
23.4x15.6x0.7 cm
Weight
0.20 kg.
ISBN
3642094376
ISBN13
9783642094378
Categories

retrotransposition, diversity and the brain

Fred H. Gage (Illustrated by) · Springer · Paperback

retrotransposition, diversity and the brain - Gage, Fred H.

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Synopsis "retrotransposition, diversity and the brain"

The human brain is remarkably complex, permitting sophisticated behavioural rep- toires, such as languages, tool use, self-awareness, symbolic thought, cultural learning and consciousness. Each human being is different, due in part to the uniqueness of the neuronal heterogeneity and interconnections in our brains. Brain complexity and neuronal diversity are strongly related. The diversity of single neurons provides the underpinnings for how neuronal circuits operate. How and when neuronal diversity is generated, both in embryonic and adult neurogenesis, remain unknown. In the immune system, the highly diverse array of antigen receptors can be - tributed to the stochastic nature of the recombination process in somatic precursor cells, causing permanent changes in DNA and gene expression. This diverse population is then the target of selective processes that favor the correct antigen-receptor match and eliminate those with inadequate speci?cities, accounting for the rapid kinetics and immense diversity observed in vivo. Evidence for a possible similarity between the nervous and immune systems came from studies with mice de?cient in DNA double strand break (DSB) repair. Lessons learned from the discovery of the mechanism for diversityinthe immune system maybe usefultothe investigation ofthe mechanism of diversity in neurons.

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