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portada Hormesis: A Revolution in Biology, Toxicology and Medicine
Hormesis: A Revolution in Biology, Toxicology and MedicineHormesis: A Revolution in Biology, Toxicology and MedicineHormesis: A Revolution in Biology, Toxicology and MedicineHormesis: A Revolution in Biology, Toxicology and Medicine
Type
Physical Book
Publisher
Author
Language
English
Pages
213
Format
Hardcover
Dimensions
23.4 x 16.0 x 1.5 cm
Weight
0.45 kg.
ISBN
9781607614944
ISBN13
9781607614944
Categories

Hormesis: A Revolution in Biology, Toxicology and Medicine

Mattson, Mark P. ; Calabrese, Edward J. (Author) · Humana · Hardcover

Hormesis: A Revolution in Biology, Toxicology and Medicine - Mattson, Mark P. ; Calabrese, Edward J.

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Synopsis "Hormesis: A Revolution in Biology, Toxicology and Medicine"

The term hormesis is de?ned as a process in which exposure to a low dose of a chemical agent or environmental factor that is damaging at higher doses induces an adaptive bene?cial effect on the cell or organism (Calabrese et al., 2007; Mattson, 2008). To survive and reproduce in harsh competitive environments, organisms and their cellular components have, through evolution, developed molecular mec- nisms to respond adaptively to various hazards or stressors that they encounter. Examples of such stressors include chemicals ingested in food and water (metals, phytochemicals, etc.), increased energy expenditure (running, ?ghting, cognitive challenges, etc.), and reduced energy availability (food scarcity), among others. In most cases, the response of the cell or organism to the stressor exhibits a biphasic dose response, with bene?cial/adaptive responses at low doses (improved fu- tion, increased resistance to damage and disease) and adverse/destructive effects (dysfunction, molecular damage, or even death) at high doses. The prevalence of the biphasic (hormetic) dose response characteristic of biological systems merits consideration of hormesis as a fundamental principle of biology."

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