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portada 18F-FDG PET/CT Pharmacokinetics & Dosimetry
Type
Physical Book
Publisher
Author
Year
2026
Language
English
Pages
52
Format
Paperback
ISBN13
9786630549584

18F-FDG PET/CT Pharmacokinetics & Dosimetry

Abdelhadi Benabdessadok;Fathi Bouzoubiri (Author) · LAP Lambert Academic Publishing · Paperback

18F-FDG PET/CT Pharmacokinetics & Dosimetry - Abdelhadi Benabdessadok;Fathi Bouzoubiri

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Synopsis "18F-FDG PET/CT Pharmacokinetics & Dosimetry"

Quantitative Pharmacokinetic Modeling and Internal Absorbed Dose Estimation of 18F-FDG in PET Imaging This book presents an integrated framework bridging dynamic pharmacokinetic modeling, volumetric image processing, and internal radiation dosimetry in PET/CT imaging. Based on practical training data from the Nuclear Research Center of Algiers (CRNA), the work establishes a robust quantitative methodology using a three-compartment kinetic model (Cp, Ce, Cm) to analyze transport rates (k1- k4) and intracellular metabolic trapping of 18F-FDG-6-PO4. Utilizing advanced medical image visualization via AMIDE, Time-Activity Curves (TACs) were extracted for critical organs and malignant tissues. Applying the Medical Internal Radiation Dose (MIRD) formalism, the study demonstrates how mathematical modeling validates organ safety, optimizes the Tumor-to-Background Ratio (TBR) at 60 minutes post-injection, and establishes personalized radiation protection protocols for clinical practice.

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