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portada Activities of Naringin-co (II) Metal Complexes: Anti-nociceptive
Type
Physical Book
Author
Publisher
Language
English
Pages
56
Format
Paperback
Dimensions
22.9 x 15.2 x 0.3 cm
Weight
0.10 kg.
ISBN13
9786203201345
Categories

Activities of Naringin-co (II) Metal Complexes: Anti-nociceptive

Lipsa Samal (Author) · Rudra Narayan Sahoo (Author) · Sudhanshu Sekhar Rout (Author) · LAP Lambert Academic Publishing · Paperback

Activities of Naringin-co (II) Metal Complexes: Anti-nociceptive - Sahoo, Rudra Narayan ; Samal, Lipsa ; Rout, Sudhanshu Sekhar

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Synopsis "Activities of Naringin-co (II) Metal Complexes: Anti-nociceptive"

The activities of flavonoid are believed to increase when they are coordinated with transition metal ions. An attempt was made to understand the contribution of the metal coordination & type of interaction between a flavonoid & metal ion & evaluation of its biological activity. In this study a new metal complex of Co(II) with naringin was synthesized & characterized by FT-IR, UV-VIS spectrophotometer. Groups of six mice were treated with Cobalt Naringin Complex (10 mg/kg body weight), administered IP. Different tests were used for evaluating the anti-nociceptive effect or the influence on behavior of the tested substances on thermal nociception, chemical nociception & spontaneous behavior. In the current study it has been evaluated that the complex has a Co(II) ion coordinated via 4 and 5 position of the flavonoid. The metal binds with the flavonoid in the ratio 1:2, which was confirmed by Jobs method. Our preliminary data for response latencies for hot-plate and tail- flick tests suggest that systemically administered CNC produces a significant analgesic effect under thermal thermal nociceptive stimulation. The spontaneous behavior assay shows a significant decrease of activity.

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